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KMID : 0882420130840040522
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Korean Journal of Medicine
2013 Volume.84 No. 4 p.522 ~ p.530
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Predictive Factors for Long-term Clinical Outcomes in Patients with Variant Angina
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Choi Myung-Ja
Jeong Myung-Ho
Cho Jae-Yeong
Lee Young-Sook
Rhee Jung-Ae
Choi Jin-Su
Sim Doo-Sun
Park Keun-Ho
Hong Young-Joon
Kim Ju-Han
Ahn Young-Keun
Cho Jeong-Gwan
Park Jong-Chun
Kang Jung-Chaee
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Abstract
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Background/Aims: The incidence of variant angina (VA) is relatively high in Korea compared with western countries, but its long-term clinical outcomes are not well defined. Methods: Patients who underwent ergonovine provocation tests at the cardiac catheterization laboratory of Chonnam National University Hospital between 1996 and 2011 were enrolled in this study (n = 1162). Of them, 686 patients with positive ergonovine provocation tests were divided into two groups: patients with cardiac events (Group I: 153 patients, 52.4 ± 11.0 years, M: F = 103: 50) and those without (Group II: 533 patients, 51.6 ± 10.7 years, M: F = 350: 183). The mean follow-up duration was 40.2 ± 38.0 months. Cardiac events were defined as cardiac death, recurrent ischemia, rehospitalization, myocardial infarction, and follow-up angiography. Clinical findings, laboratory and coronary angiographic characteristics were compared between the groups. Results: A history of smoking was more common in Group I than in Group II (45.8% vs. 36.3%, p = 0.037). The levels of low-density lipoprotein cholesterol (119.4 ± 35.3 vs. 111.1 ± 32.2 mg/dL, p = 0.010) were higher in Group I than in Group II. According to Cox proportional hazard regression analysis, the major predictive factor for cardiac events during clinical follow-up was smoking (HR 1.80, 95% CI 1.036-3.126, p = 0.037). Conclusions: A history of smoking was the only independent risk factor for cardiac events during a long-term clinical follow-up in Korean patients with variant angina.
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KEYWORD
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Smoking, Coronary artery disease, Angina pectoris, Variant
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